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Sterigmatocystine

CAT: 0804-HY-N6725-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6725-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].
CAS Number
10048-13-2
UNSPSC
12352005
Hazard Statement
H301, H351
Target
Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/sterigmatocystine.html
Purity
99.74
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[C@]5([H])[C@@]4([H])C=CO5)C=C2OC
Molecular Formula
C18H12O6
Molecular Weight
324.28
Precautions
H301, H351
References & Citations
[1]Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16 (4) :224-31.|[2]Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30 (4) :589-91.|[3]Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42 (4) :1645-1656.|[4]Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8 (5) :e65044.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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