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α-Conotoxin EI

CAT: 0804-HY-P1266Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-P1266Size:Inquire
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CAS Number
[170663-33-9]
UNSPSC Description
α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors[1][2][3].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N2[C@](CCC2)([H])C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@](C(N[C@@H](CSSC1)C(N)=O)=O)([H])[C@@H](C)CC)=O)CCC(N)=O)=O)=O)CC(N)=O)=O)CO)=O)CCSC)=O)CC(N)=O)=O)([H])CSSC4)=O)([H])[C@H](O)C)=O)=O)CC5=CN=CN5)=O)CC6=CC=C(C=C6)O)=O)[C@H]4NC([C@H]7N(C[C@@H](C7)O)C([C@H](CC(O)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O
Molecular Weight
2093.37
References & Citations
[1]Martinez JS, et al. alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 1995 Nov 7;34(44):14519-26.|[2]Ning J, et al. Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor. Toxins (Basel). 2019 Oct 16;11(10):603.|[3]López-Vera E, et al. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 2007 Aug;274(15):3972-85.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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