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Haemanthamine (hydrochloride)

CAT: 0804-HY-114489B-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114489B-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].
UNSPSC
12352005
Target
Apoptosis; Influenza Virus; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/haemanthamine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1)[C@@]2(C=C3)C4=CC(OCO5)=C5C=C4C[N@@]1[C@@]2([H])C[C@@H]3OC.[H]Cl
Molecular Formula
C17H20ClNO4
Molecular Weight
337.80
References & Citations
[1]Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26 (3) :416-425.e4.|[2]Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

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