GSK2647544

CAT: 0804-HY-145653-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-145653-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].

CAS Number

1380426-95-8

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gsk2647544.html

Purity

99.50

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC(OCCC2=CC=C(C=C2)OC3=CC=C(C(C(F)(F)F)=C3)Cl)=NC=C1CC4=CN=CN=C4

Molecular Formula

C24H18ClF3N4O3

Molecular Weight

502.87

References & Citations

[1]Wu K, et al. Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers . Int J Clin Pharmacol Ther. 2016;54 (12) :935-949.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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