Val-Cit

• Description :

  Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

• CAS Number :

  [159858-33-0]

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/val-cit.html

• Purity :

  99.76

• Solubility :

  H2O : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O

• Molecular Formula :

  C11H22N4O4

• Molecular Weight :

  274.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Protease Cleavable Linker