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Fmoc-Val-D-Cit-PAB

CAT: 0804-HY-19318ASize: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19318ASize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC) [1].
CAS Number
1350456-67-5
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-val-d-cit-pab.html
Purity
99.23
Solubility
10 mM in DMSO
Smiles
OCC(C=C1)=CC=C1NC([C@@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O
Molecular Formula
C33H39N5O6
Molecular Weight
601.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Mondal D, et al. Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research. Tetrahedron Lett. 2018;59 (40) :3594-3599.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Protease Cleavable Linker

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