Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [PSH08-83]

Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [PSH08-83]

• Description: Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function. In Parkinson's disease and other synucleinopathies, insoluble forms of alpha-synuclein accumulate as inclusions in Lewy bodies. Familial Parkinson's disease is associated with mutations in the -synuclein (SNCA) gene. In the process of seeded nucleation, alpha-synuclein acquires a cross-sheet structure similar to other amyloids.
• Product Name Alternative: Alpha synuclein antibody Alpha-synuclein antibody Alpha-synuclein, isoform NACP140 antibody alphaSYN antibody MGC105443 antibody MGC110988 antibody MGC127560 antibody MGC64356 antibody NACP antibody Non A beta component of AD amyloid antibody Non A4 component of amyloid antibody Non A4 component of amyloid precursor antibody Non-A beta component of AD amyloid antibody Non-A-beta component of alzheimers disease amyloid , precursor of antibody Non-A4 component of amyloid precursor antibody Non-A4 component of amyloid, precursor of antibody OTTHUMP00000218549 antibody OTTHUMP00000218551 antibody OTTHUMP00000218552 antibody OTTHUMP00000218553 antibody OTTHUMP00000218554 antibody PARK 1 antibody PARK 4 antibody PARK1 antibody PARK4 antibody Parkinson disease (autosomal dominant, Lewy body) 4 antibody Parkinson disease familial 1 antibody SNCA antibody Snca synuclein antibody Snca synuclein, alpha (non A4 component of amyloid precursor) antibody SYN antibody Synuclein alpha antibody Synuclein alpha 140 antibody Synuclein, alpha (non A4 component of amyloid precursor) antibody SYUA_HUMAN antibody
• Abbreviation: Alpha-synuclein Non-A beta component of AD amyloid Non-A4 component of amyloid precursor (NACP) SNCA NACP, PARK1
• CAS Number: 9000-83-3
• Swiss Prot: P37840 Human, O55042 Mouse, P37377 Rat
• Cellular Locus: Cytoplasm, Membrane, Nucleus, Synapse, Secreted, Cell projection, axon.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Alpha-Synuclein aa 1-140.
• Isotype: IgG
• Clone: PSH08-83
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IHC-Fr, IF-Tissue
• Positive Control: Mouse cerebellum tissue, rat cerebellum tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000-1:5,000 ;IHC-P: 1:5,000 ;IHC-Fr: 1:500 ;IF-Tissue: 1:500-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 14 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes