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DTP348

CAT: 0804-HY-120367Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120367Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DTP348 is an inhibitor for carbonic anhydrase IX with a Ki of 8.3 nM in vitro and an IC50 of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with LD50 of 3.5 mM. DTP348 can be used in the anti-cancer research[1].
CAS Number
1383370-92-0
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dtp348.html
Smiles
O=S(NCCN1C([N+]([O-])=O)=CN=C1C)(N)=O
Molecular Formula
C6H11N5O4S
Molecular Weight
249.25
References & Citations
[1]Aspatwar A, et al., Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. J Enzyme Inhib Med Chem. 2018 Dec;33 (1) :1064-1073.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CA IX

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