Furazolidone

CAT: 0804-HY-B1336-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-B1336-01Size:100 mg

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Description

Furazolidone is a monoamine oxidase (MAO) inhibitor with antiproliferative, apoptosis-inducing and differentiation-promoting activities. Furazolidone may inhibit leukemia fusion protein-mediated bone marrow transformation by upregulating the stability of the tumor suppressor protein p53. Furazolidone exhibits anti-leukemic activity in acute myeloid leukemia (AML) cell lines and can be used for anti-AML research[1][2].

CAS Number

67-45-8

UNSPSC

12352005

Hazard Statement

H361

Target

Antibiotic; Apoptosis; Bacterial; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Furazolidone.html

Purity

99.87

Solubility

DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1OCCN1/N=C/C2=CC=C([N+]([O-])=O)O2

Molecular Formula

C8H7N3O5

Molecular Weight

225.16

Precautions

H361

References & Citations

[1]Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8 (8) :e72335.|[2]Ma S, et al. Furazolidone Increases Survival of Mice Exposed to Lethal Total Body Irradiation through the Antiapoptosis and Antiautophagy Mechanism. Oxid Med Cell Longev. 2021 Feb 4;2021:6610726.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Chemical Information

Furazolidone

Furazolidone can cause cancer according to The Environmental Protection Agency (EPA).

CAS Number	67-45-8
PubChem CID	5323714
IUPAC Name	3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
Molecular Formula	C8H7N3O5
Molecular Weight	225.16
XLogP	-0.1
Topological Polar Surface Area	101
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	16
Formal Charge	0
Complexity	326

SMILES

C1COC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-]

InChI

InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

InChIKey

PLHJDBGFXBMTGZ-WEVVVXLNSA-N

Chemical Structure

2D Structure

CAS: 67-45-8

CID: 5323714

Formula: C8H7N3O5

MW: 225.16

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	225.16
XLogP3	-0.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	225.03857033
Monoisotopic Mass	225.03857033
Topological Polar Surface Area	101 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	326
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
B2697-5G	Furazolidone

Furazolidone

Chemical Information

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