Human Brorin, VWC2 ELISA Kit

CAT: 1360-BPE241-01Size: 96 TestsDry Ice: NoHazardous: No

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CAT#:1360-BPE241-01Size:96 Tests

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Background

Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein that contains two VWFC domains. VWC2 / Brorin is a BMP antagonist that may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.

Product Name Alternative

Brorin

Synonyms

PSST739

Gene Name

VWC2

Gene ID

375567

UniProt

Q2TAL6

Target

VWC2

Field of Research

Metabolism

Assay Type

Sandwich

Assay Protocol

Concentration | O.D. | Average | Corrected ------------------------------------------ 500 pg/ml | 1.669 | 1.662 | 1.564 1.656 250 pg/ml | 1.073 | 1.117 | 1.019 1.161 125 pg/ml | 0.734 | 0.719 | 0.621 0.704 62.5 pg/ml | 0.423 | 0.421 | 0.323 0.419 31.25 pg/ml | 0.276 | 0.261 | 0.163 0.246 15.625 pg/ml | 0.167 | 0.169 | 0.071 0.172 7.8125 pg/ml | 0.126 | 0.135 | 0.037 0.144 0 pg/ml | 0.092 | 0.098 | 0 0.105

Assay Performance Time

3.5h

Sample Type

Serum, plasma, cell culture supernates

Detection Range

7.81-500 pg/mL

Precision

Intra/Inter-Assay | Sample | n | Mean | Standard Deviation | CV% ---------------------------------------------------------------- Intra-assay | 1 | 20 | 36.6 | 1.7 | 4.7 Intra-assay | 2 | 20 | 96.4 | 3.4 | 3.5 Intra-assay | 3 | 20 | 301 | 6.4 | 2.1 Inter-assay | 1 | 20 | 36.5 | 1.5 | 4.2 Inter-assay | 2 | 20 | 96.6 | 2.8 | 2.8 Inter-assay | 3 | 20 | 301 | 7 | 2.3

Sensitivity

1.52 pg/mL

Components

Storage Temperature

2-8°C

Species

Human

Mass

35282

UniProtKB · Q2TAL6

Brorin

VWC2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q2TAL6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: VWC2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: Q6UXE2

Protein keywords

Cellular component

Basement membraneExtracellular matrixSecretedSynapse

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignal

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