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Lanraplenib (GS-SYK)

CAT: 1568-C14435-1gSize: 1 gDry Ice: NoHazardous: No
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CAT#:1568-C14435-1gSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1800046-95-0
Synonyms
GS-9876
Target
Syk
Applications
Protein Tyrosine Kinase
Smiles
NC1=CN=CC (=N1) C2=C[N]3C=CN=C3C (=N2) NC4=CC=C (C=C4) N5CCN (CC5) C6COC6
Molecular Formula
C23H25N9O
Additionnal Information
Lanraplenib (GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
Storage Conditions
3 years -20°C powder

Chemical Information

Lanraplenib

Lanraplenib is under investigation in clinical trial NCT03285711 (Safety and Efficacy of Filgotinib and Lanraplenib in Adults With Lupus Membranous Nephropathy (LMN)).

CAS Number1800046-95-0
PubChem CID118161062
IUPAC Name6-(6-aminopyrazin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
Molecular FormulaC23H25N9O
Molecular Weight443.5
XLogP1.4
Topological Polar Surface Area110
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity635
SMILES
C1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N
InChI
InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)
InChIKey
XCIGZBVOUQVIPI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lanraplenib
CAS: 1800046-95-0
CID: 118161062
Formula: C23H25N9O
MW: 443.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.5
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass443.21820645
Monoisotopic Mass443.21820645
Topological Polar Surface Area110 Ų
Heavy Atom Count33
Formal Charge0
Complexity635
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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