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TBK1/IKKε-IN-5

CAT: 1568-C13785-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C13785-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1893397-65-3
Synonyms
Compound 1
Target
IκB/IKK
Applications
NF-κB
Smiles
C1COCCC1OC2=C (C=C (C=C2) C3=NC (=NC=N3) NC4=CC=C (C=C4) N5CCN (CC5) C6COC6) C#N
Molecular Formula
C28H31N7O3
Additionnal Information
TBK1/IKKε-IN-5 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.
Storage Conditions
3 years -20°C powder

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S8922-100mgTBK1/IKKε-IN-5
A18400-100TBK1/IKKε -IN-5 100mg
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A18400-50TBK1/IKKε -IN-5 50mg
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A18400-5TBK1/IKKε -IN-5 5mg
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