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GMB-475

CAT: 1568-C13752-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C13752-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2490599-18-1
Target
Bcr-Abl
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (SC=N1) C2=CC=C (CNC (=O) C3CC (O) CN3C (=O) C (NC (=O) COCCOC4=CC=C (C=C4) C5=CC (=NC=N5) NC6=CC=C (OC (F) (F) F) C=C6) C (C) (C) C) C=C2
Molecular Formula
C43H46F3N7O7S
Additionnal Information
GMB-475 is a proteolysis-targeting chimera (PROTAC) that allosterically targets BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
Storage Conditions
3 years -20°C powder

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ARC0871SNU-475
HY-W953768CRBN ligand-475
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HY-13099717-GMB-APA-GA

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