Products for Research Use Only
RegisterLogin

GMB-475

CAT: 0931-T8488-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T8488-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2490599-18-1
Target
STAT, JAK, Apoptosis, PROTACs, Bcr-Abl
Related Pathways
Chromatin/Epigenetic, Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, PROTAC, Cytoskeletal Signaling, JAK/STAT signaling, Stem Cells
Purity
>99.99%
Bioactivity
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL) .resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(cc2)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)C(C)(C)C)cc1
Molecular Formula
C43H46F3N7O7S
Molecular Weight
861.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T4019117-GMB-APA-GA
T15395-01GMBS
T64569Sulfo-GMBS
T70136-01CAM 4750
T70091-01IACS-4759

Alternative Products

CatalogName
C13752-25mgGMB-475
7265/5GMB 475
ARC0871SNU-475
HY-W953768CRBN ligand-475
T1182SNU-475 Cells
HY-13099717-GMB-APA-GA

Popular Products