GMB-475

CAT: 0931-T8488-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T8488-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2490599-18-1
Target
STAT|||JAK|||Apoptosis|||PROTACs|||Bcr-Abl
Related Pathways
Chromatin/Epigenetic|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis|||PROTAC|||Cytoskeletal Signaling|||JAK/STAT signaling|||Stem Cells
Purity
>99.99%
Bioactivity
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL) .resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(cc2)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)C(C)(C)C)cc1
Molecular Formula
C43H46F3N7O7S
Molecular Weight
861.93
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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