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SD-208

CAT: 1568-C12824-10mM/1mLSize: 10 mm/ 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C12824-10mM/1mLSize:10 mm/ 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
627536-09-8
Target
TGF-beta/Smad
Applications
TGF-beta/Smad
Smiles
C1=CC (=C (C=C1Cl) C2=NC3=NC=CN=C3C (=N2) NC4=CC=NC=C4) F
Molecular Formula
C17H10ClFN6
Additionnal Information
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.
Storage Conditions
2 years -80 in solvent

Chemical Information

SD-208

selective and potent orally active TGF-beta receptor I kinase inhibitor

CAS Number627536-09-8
PubChem CID10316032
IUPAC Name2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
Molecular FormulaC17H10ClFN6
Molecular Weight352.8
XLogP3
Topological Polar Surface Area76.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity437
SMILES
C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
InChI
InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChIKey
BERLXWPRSBJFHO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SD-208
CAS: 627536-09-8
CID: 10316032
Formula: C17H10ClFN6
MW: 352.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.8
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass352.0639502
Monoisotopic Mass352.0639502
Topological Polar Surface Area76.5 Ų
Heavy Atom Count25
Formal Charge0
Complexity437
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS131434SD-208 (SD 208; SD208)
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