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Cilofexor (GS-9674)

CAT: 1568-C11995-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C11995-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1418274-28-8
Synonyms
GS-9674
Target
FXR
Applications
Metabolism
Smiles
C1CC1C2=C (C (=NO2) C3=C (C=CC=C3Cl) Cl) COC4=CC (=C (C=C4) C5 (CN (C5) C6=NC=CC (=C6) C (=O) O) O) Cl
Molecular Formula
C28H22Cl3N3O5
Additionnal Information
Cilofexor (GS-9674) is a potent, selective oral agonist of farnesoid X receptor (FXR) with an EC50 of 43 nM. It has demonstrated anti-inflammatory, antifibrotic effects, and reduced portal pressure in preclinical liver fibrosis models, showing potential therapeutic benefit for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research.

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