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AZD6482

CAT: 1568-C07816-5mgSize: 5 mgDry Ice: YesHazardous: No
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CAT#:1568-C07816-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1173900-33-8
Synonyms
KIN-193
Target
PI3K
Applications
PI3K/Akt/mTOR
Smiles
CC1=CN2C (=O) C=C (N=C2C (=C1) C (C) NC3=CC=CC=C3C (=O) O) N4CCOCC4
Molecular Formula
C22H24N4O4
Additionnal Information
AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.
Storage Conditions
2 years -80 in solvent

Chemical Information

Azd-6482

2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid is a pyridopyrimidine.

CAS Number1173900-33-8
PubChem CID44137675
IUPAC Name2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid
Molecular FormulaC22H24N4O4
Molecular Weight408.4
XLogP2
Topological Polar Surface Area94.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity838
SMILES
CC1=CN2C(=O)C=C(N=C2C(=C1)[C@@H](C)NC3=CC=CC=C3C(=O)O)N4CCOCC4
InChI
InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m1/s1
InChIKey
IRTDIKMSKMREGO-OAHLLOKOSA-N
Chemical Structure
2D Structure
2D structure of Azd-6482
CAS: 1173900-33-8
CID: 44137675
Formula: C22H24N4O4
MW: 408.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight408.4
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass408.17975526
Monoisotopic Mass408.17975526
Topological Polar Surface Area94.5 Ų
Heavy Atom Count30
Formal Charge0
Complexity838
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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