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Alfuzosin HCl

CAT: 1568-C16302-50mgSize: 50 mgDry Ice: YesHazardous: No
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CAT#:1568-C16302-50mgSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
81403-68-1
Synonyms
SL 77499 HCl
Target
Adrenergic Receptor
Applications
Neuronal Signaling
Smiles
CN (CCCNC (=O) C1CCCO1) C2=NC3=CC (=C (C=C3C (=N2) N) OC) OC.Cl
Molecular Formula
C19H27N5O4.HCl
Additionnal Information
Alfuzosin HCI (SL 77499 HCl) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH) .
Storage Conditions
2 years -80 in solvent

Chemical Information

Alfuzosin Hydrochloride

Alfuzosin Hydrochloride is the hydrochloride salt of alfuzosin, a quinazoline compound with smooth muscle-relaxing activity. Alfuzosin selectively binds to and antagonizes post-synaptic alpha-1-adrenoreceptors in smooth muscle of the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra, initiating relaxation of smooth muscle and resulting in improvement of urine flow and the symptoms of benign prostatic hyperplasia (BPH). This agent also blocks alpha-1-adrenoreceptors in peripheral vascular smooth muscle, resulting in vasodilatation and a decrease in peripheral vascular resistance.

CAS Number81403-68-1
PubChem CID71764
IUPAC NameN-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide;hydrochloride
Molecular FormulaC19H28ClN5O4
Molecular Weight425.9
Topological Polar Surface Area112
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count29
Formal Charge0
Complexity511
SMILES
CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl
InChI
InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H
InChIKey
YTNKWDJILNVLGX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Alfuzosin Hydrochloride
CAS: 81403-68-1
CID: 71764
Formula: C19H28ClN5O4
MW: 425.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight425.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass425.1829821
Monoisotopic Mass425.1829821
Topological Polar Surface Area112 Ų
Heavy Atom Count29
Formal Charge0
Complexity511
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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