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Agomelatine hydrochloride

CAT: 1568-C03665-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C03665-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1176316-99-6
Synonyms
S-20098 hydrochloride
Target
MT Receptor
Applications
Neuronal Signaling
Molecular Formula
C15H17NO2.ClH
Additionnal Information
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of these receptors enhances adrenergic and dopaminergic transmission in the frontocortical regions.

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