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Glafenine

CAT: 1568-C03437-50mgSize: 50 mgDry Ice: NoHazardous: No
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CAT#:1568-C03437-50mgSize:50 mg
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CAS Number
3820-67-5
Synonyms
Glafenin
Target
Others
Applications
Others
Molecular Formula
C19H17ClN2O4
Additionnal Information
Glafenine (Glafenin) is a non-steroidal anti-inflammatory drug (NSAID) and is a non-narcotic analgesic agent that not only acts as a proteostasis modulator but is also one of the most potent NSAID correctors of F508del-CFTR. It exhibits COX-2 inhibition in the arachidonic acid pathway and rescues class 2 CFTR mutants.

Chemical Information

Glafenine

Glafenine is a carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market. It has a role as an inhibitor, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a glycol, a carboxylic ester, an organochlorine compound, an aminoquinoline and a secondary amino compound. It is functionally related to a glycerol and an anthranilic acid.

CAS Number3820-67-5
PubChem CID3474
IUPAC Name2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
Molecular FormulaC19H17ClN2O4
Molecular Weight372.8
XLogP3.5
Topological Polar Surface Area91.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count26
Formal Charge0
Complexity467
SMILES
C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC(=CC3=NC=C2)Cl
InChI
InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)
InChIKey
GWOFUCIGLDBNKM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Glafenine
CAS: 3820-67-5
CID: 3474
Formula: C19H17ClN2O4
MW: 372.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.8
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass372.0876847
Monoisotopic Mass372.0876847
Topological Polar Surface Area91.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity467
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-B1153-01Glafenine
A24321-500Glafenine 500mg
BUP14636Glafenine Hydrochloride
HY-B1153A-01Glafenine (hydrochloride)
HY-B1153R-01Glafenine (Standard)
A24321-100Glafenine 100mg
sc-495725Glafenine-d4
sc-495670Glafenine N-Oxide

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