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Glafenine (Standard)

CAT: 0804-HY-B1153R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1153R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glafenine (Standard) is the analytical standard of Glafenine. This product is intended for research and analytical applications. Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) [1][2][3][4].
CAS Number
3820-67-5
UNSPSC
12352100
Hazard Statement
H315, H319, H335
Target
Apoptosis; CFTR; COX; Endoplasmic Reticulum Oxidoreductase 1 (ERO1) ; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease; Inflammation/Immunology
Purity
98.59
Smiles
O=C(OCC(O)CO)C1=CC=CC=C1NC2=CC=NC3=CC(Cl)=CC=C23
Molecular Formula
C19H17ClN2O4
Molecular Weight
372.80
Precautions
H315, H319, H335
References & Citations
[1]Schöber W, et al. Impact of glafenine hydrochloride on human endothelial cells and human vascular smooth muscle cells: a substance reducing proliferation, migration and extracellular matrix synthesis. Cell Biol Int. 2003;27 (12) :987-96|[2]Carlile GW, et al. The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway. Sci Rep. 2022 Mar 17;12 (1) :4595|[3]Goldsmith JR, et al. Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. Dis Model Mech. 2013 Jan;6 (1) :146-59.|[4]Chiu AM, et al. High Throughput Assay Identifies Glafenine as a Corrector for the Folding Defect in Corneal Dystrophy-Causing Mutants of SLC4A11. Invest Ophthalmol Vis Sci. 2015 Dec;56 (13) :7739-53.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

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