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BTX-A51

CAT: 1568-C01686-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01686-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2079068-74-7
Synonyms
Casein Kinase inhibitor A51
Target
CDK
Applications
Cell Cycle
Molecular Formula
C18H25ClN6
Additionnal Information
BTX-A51 (Casein Kinase inhibitor A51) is a first-in-class oral and potent inhibitor of casein kinase 1α (CK1α) and cyclin dependent kinase (CDK7/9) with an IC50 of 17 nM for CK1α and Kd of 1.3 nM and 4 nM for CDK7 and CDK9, respectively. It induces apoptosis of leukemic cells by activating p53 and inhibiting expression of Mcl1 and can be used in Acute myeloid leukemia (AML) cancer research.

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