Products for Research Use Only
RegisterLogin

NGD94-1

CAT: 0804-HY-103405-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-103405-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NGD94-1 is a potent and selective dopamine D4 receptor antagonist. NGD94-1 shows high affinity for the cloned human D4.2 receptor (Ki = 3.6 nM) . NGD94-1 modulates the cognitive functions of the frontostriatal system and regulates dopaminergic transmission in Phencyclidine (PCP) -induced monkeys. NGD94-1 can be used for neurological disease research[1][2].
CAS Number
178928-68-2
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ngd94-1.html
Purity
99.73
Solubility
10 mM in DMSO
Smiles
C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1
Molecular Formula
C18H20N6
Molecular Weight
320.39
References & Citations
[1]Jentsch JD, et al. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology (Berl) . 1999 Feb;142 (1) :78-84. |[2]Tallman JF, et al. I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1011-9. |[3]Gazi L, et al. NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells. Eur J Pharmacol. 1999 May 21;372 (3) :R9-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
D4 Receptor

Related Products

CatalogName
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-149536TWIK-1/TREK-1-IN-1
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-133630-011-Bromo-1,1-dichloroacetone
HY-1336291,1,1,3-Tetrachloroacetone
HY-W881439-011- (1,1-Dimethylethyl) tridecanedioate
HY-W032015S11-Bromooctane-1,1-d2
HY-112773-011,1′,1′′,1′′′-[1,4-Piperazinediylbis (2,1-ethanediylnitrilo) ]tetrakis[2-dodecanol]

Alternative Products

CatalogName
OF59775-011,1,1,1,1-Kestoheptaose
N2864-5.11,1,1,1-Kestohexaose
1120401,1,1,1-Kestohexose
410417-011,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-011-Iodobicyclo[1.1.1]pentane
OR3123881-Phenylbicyclo[1.1.1]pentane
GTR19217879-01AMPK-α1β1γ1 activator 1
OR3001791-Isothiocyanatobicyclo[1.1.1]pentane
OR3001741-Isocyanatobicyclo[1.1.1]pentane
DFA88480-011-Bromobicyclo[1.1.1]pentane

Popular Products