MPEG-Mal (MW 5000)

• Description:

  MPEG-Mal (MW 5000) (mPEG-Maleimide (MW 5000) ) is a PEG derivative and a thiol-specific chemical modification reagent. mPEG-Mal (MW 5000) can react with free cysteines in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa to facilitate detection . mPEG-Mal (MW 5000) can also be used in research related to drug delivery to improve the stability and activity of drugs[1][2].

• Product Name Alternative:

  MPEG-Maleimide (MW 5000)

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/methoxypolyethylene-glycol-maleimide.html

• Purity:

  99.91

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  COCCOCCNC(CCN1C(C=CC1=O)=O)=O.[n]

• Molecular Weight:

  5000 (Average)

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Pan LQ, et al. Site-specific PEGylation of a mutated-cysteine residue and its effect on tumor necrosis factor (TNF) -related apoptosis-inducing ligand (TRAIL) . Biomaterials. 2013 Dec;34 (36) :9115-23.|[2]Chen C, et al. Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2 (SNAT2) by Chemical Modification. PLoS One. 2016 Jun 29;11 (6) :e0158319.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  724722-89-8