Products for Research Use Only
RegisterLogin

BD750

CAT: 0804-HY-131140-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-131140-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].
CAS Number
892686-59-8
UNSPSC
12352005
Hazard Statement
H301
Target
JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bd750.html
Purity
99.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C2CCCCC2=NN1C3=NC4=CC=CC=C4S3
Molecular Formula
C14H13N3OS
Molecular Weight
271.34
Precautions
H301
References & Citations
[1]Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168 (3) :632-43.|[2]Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3; STAT5

Alternative Products

CatalogName
BA4902-5BD750
A22300-50BD750 50mg
A22300-100BD750 100mg
A22300-10BD750 10mg
A22300-25BD750 25mg
A22300-5BD750 5mg
A22300-10mM-DBD750 10mM * 1mL in DMSO

Popular Products