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BD750

CAT: 0804-HY-131140-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131140-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].
CAS Number
892686-59-8
UNSPSC
12352005
Hazard Statement
H301
Target
JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bd750.html
Purity
99.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C2CCCCC2=NN1C3=NC4=CC=CC=C4S3
Molecular Formula
C14H13N3OS
Molecular Weight
271.34
Precautions
H301
References & Citations
[1]Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168 (3) :632-43.|[2]Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3; STAT5

Chemical Information

2-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
CAS Number892686-59-8
PubChem CID16459674
IUPAC Name2-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydro-1H-indazol-3-one
Molecular FormulaC14H13N3OS
Molecular Weight271.34
XLogP3.5
Topological Polar Surface Area73.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity436
SMILES
C1CCC2=C(C1)C(=O)N(N2)C3=NC4=CC=CC=C4S3
InChI
InChI=1S/C14H13N3OS/c18-13-9-5-1-2-6-10(9)16-17(13)14-15-11-7-3-4-8-12(11)19-14/h3-4,7-8,16H,1-2,5-6H2
InChIKey
QWUHPPCZZXKXOQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
CAS: 892686-59-8
CID: 16459674
Formula: C14H13N3OS
MW: 271.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight271.34
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass271.07793322
Monoisotopic Mass271.07793322
Topological Polar Surface Area73.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity436
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3612099-01BD750
A22300-50BD750 50mg
A22300-100BD750 100mg
A22300-10BD750 10mg
A22300-5BD750 5mg
A22300-25BD750 25mg
A22300-10mM-DBD750 10mM * 1mL in DMSO

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