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Loureirin B

CAT: 0804-HY-N1504-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1504-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
CAS Number
119425-90-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ERK; JNK; PAI-1; Potassium Channel
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Loureirin_B.html
Purity
99.95
Solubility
DMSO : ≥ 150 mg/mL
Smiles
O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(OC)C=C2OC
Molecular Formula
C18H20O5
Molecular Weight
316.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Sha Y, et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17.|[2]He T, et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37 (2) :666-76.|[3]Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24 (5) :355-60.|[4]Yu Jiang, et al. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evidence-Based Complementary and Alternative Medicine
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERK; JNK

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