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Ezlopitant

CAT: 0804-HY-106982-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106982-01Size:1 mg
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Description
Ezlopitant (CJ-11,974) is a selective, non-peptidic neurokinin-1 (NK-1) -receptor antagonist. Ezlopitant inhibits both acute and delayed emetic reactions induced by Cisplatin in ferrets via acting on NK1 receptors in the central nervous system. Ezlopitant has the potential for pain, chemotherapy-induced emesis and irritable bowel syndrome research[1][2][3].
CAS Number
147116-64-1
Product Name Alternative
CJ-11,974
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ezlopitant.html
Solubility
10 mM in DMSO
Smiles
COC(C=CC(C(C)C)=C1)=C1CN[C@@H](C2CCN3CC2)[C@@H]3C(C4=CC=CC=C4)C5=CC=CC=C5
Molecular Formula
C31H38N2O
Molecular Weight
454.65
References & Citations
[1]Pia Steensland, et al. The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol. PLoS One. 2010 Sep 1;5 (9) :e12527. |[2]A E Reed-Hagen, et al. Pharmacokinetics of ezlopitant, a novel non-peptidic neurokinin-1 receptor antagonist in preclinical species and metabolite kinetics of the pharmacologically active metabolites. Biopharm Drug Dispos. 1999 Dec;20 (9) :429-39.|[3]Megumi Tsuchiya, et al. Anti-emetic activity of the novel nonpeptide tachykinin NK1 receptor antagonist ezlopitant (CJ-11,974) against acute and delayed cisplatin-induced emesis in the ferret. Pharmacology. 2002 Nov;66 (3) :144-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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