S-Adenosyl-L-methionine (disulfate tosylate)

• UNSPSC Description:

  S-Adenosyl-L-methionine disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

• Target Antigen:

  Apoptosis; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/S-Adenosyl-L-methionine_disulfate_tosylate.html

• Purity:

  98.80

• Solubility:

  DMSO : ≥ 50 mg/mL|H2O : 33.33 mg/mL (ultrasonic)

• Smiles:

  N[C@@H](CC[S+](C[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)O)C)C(O)=O.O=S(O)([O-])=O.O=S(O)(O)=O.OS(=O)(C4=CC=C(C)C=C4)=O

• Molecular Weight:

  766.80

• References & Citations:

  [1]Lu SC, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.|[2]Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.|[3]Najm WI, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.|[4]Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. |[5]Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. |[6]Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74.|[7]Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157.Pharmacol Res. 2024 Sep 16:107420.|Biochem Pharmacol. 2023 Dec 6:219:115967.|bioRxiv. 2023 Jun 1.|Epigenetics Chromatin. 2021 Dec 4;14(1):52.|Int Immunopharmacol. 2021 Mar 22;95:107545.|J Agric Food Chem. 2021 Jul 30.|Research Square Preprint. 2020 Aug.|Research Square Preprint. 2021 Jun.|J Cell Physiol. 2024 Oct 6:e31452.|Molecules. 2023 Apr 11, 28(8), 3375.|J Pharm Biomed Anal. 2024 Jan 20, 115991.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  97540-22-2