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Factor B (Bb) Protein

CAT: 1008-A416Size: 250 µLDry Ice: NoHazardous: No
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CAT#:1008-A416Size:250 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Centrally important to the alternative pathway is the zymogen Factor B. Factor B is a 93 kD protein which is converted to an active proteolytic enzyme via a two step reaction involving C3b and Factor D. Factor B binds to C3b (or hydrolyzed C3) either in fluid phase or on a membrane or other surface. In the second step, Factor D cleaves the bound Factor B to yield Ba (33 kD) and Bb (60KD) The resulting bimolecular complex is the alternative pathway convertase and is capable of cleaving additional C3 or, together with a second C3b molecule, C5.
Description
Purified human Factor Bb protein
Source
Normal human serum
Applications
See citations and technical data sheet for application info.
Concentration
1.0 mg/mL (refer to CoA for lot specific concentration)
Purity
>90% by SDS-PAGE
Activity
No activity
Form
Frozen liquid. Phosphate-buffered saline, pH 7.2 No preservative, 0.22 μm filtered.
Molecular Weight
60,000 Da (single chain)
Storage Conditions
Store at -70°C or below. Avoid freeze/thaw.

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