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Paromomycin (sulfate)

CAT: 0804-HY-B0956-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0956-01Size:500 mg
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Description
Paromomycin (Aminosidine) sulfate, a neomycin derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3].
CAS Number
1263-89-4
Product Name Alternative
Aminosidine (sulfate)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Bacterial; Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Paromomycin-sulfate.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : < 1 mg/mL|Ethanol : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CO.O=S(O)(O)=O
Molecular Formula
C23H47N5O18S
Molecular Weight
713.71
Precautions
H315, H319, H335
References & Citations
[1]Tony J Tavares, et al. Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. RNA. 2009 May;15 (5) :911-22.|[2]Mohamed Mammeri, et al. Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice. Exp Parasitol. 2018 Nov;194:1-8.|[3]Ibrahim Aly, et al. Efficacy of Low and High Dose of Paromomycin Sulfate for Treatment of Cryptosporidiosis in Immunosuppressed Infected-Mice.Global Veterinaria 15 (2) : 137-143, 2015
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Amebae; Aminoglycoside

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