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HGC652

CAT: 0957-E6651-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E6651-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3055558-98-7
Target
Molecular Glues
Applications
Others
Smiles
CN (C (C1=CC=C (C2=C (SC) C=C (F) C=C2) C=C1S (=O) (C) =O) =O) CC3CCCCC3
Molecular Formula
C23H28FNO3S2
Additionnal Information
HGC652 functions as a molecular glue by targeting E3 ubiquitin ligase TRIM21. It facilitates the formation of a TRIM21-NUP98 ternary complex, leading to degradation of NUP155 and nuclear pore complex proteins, ultimately resulting in cell death. The compound shows inhibitory effects on the proliferation of various cancer cell lines, with activity dependent on TRIM21 expression levels.

Alternative Products

CatalogName
C18348-01HGC652

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