Uzansertib (INCB053914)

CAT: 0957-S8800-1mgSize: 1 mgDry Ice: NoHazardous: No

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CAT#:0957-S8800-1mgSize:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2088852-47-3

Target

Pim

Applications

JAK/STAT

Smiles

CC1CN (CC (C1O) N) C2=C3CCC (C3=NC=C2NC (=O) C4=NC (=C (C=C4) F) C5=C (C=CC=C5F) F) O.OP (=O) (O) O

Molecular Formula

C26H26F3N5O3.H3O4P

Additionnal Information

Uzansertib (INCB053914) is a novel, ATP-competitive, small molecule, pan-inhibitor of PIM kinases with IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays.

Storage Conditions

3 years -20°C powder

Chemical Information

Uzansertib

Uzansertib is under investigation in clinical trial NCT02587598 (Study of INCB053914 in Subjects With Advanced Malignancies).

CAS Number	2088852-47-3
PubChem CID	90279868
IUPAC Name	N-[(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
Molecular Formula	C26H26F3N5O3
Molecular Weight	513.5
XLogP	1.7
Topological Polar Surface Area	125
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	4
Heavy Atom Count	37
Formal Charge	0
Complexity	803

SMILES

C[C@H]1CN(C[C@H]([C@@H]1O)N)C2=C3CC[C@H](C3=NC=C2NC(=O)C4=NC(=C(C=C4)F)C5=C(C=CC=C5F)F)O

InChI

InChI=1S/C26H26F3N5O3/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37)/t12-,17+,20+,25+/m0/s1

InChIKey

PTORCEYGCGXHDH-OVMXCRKPSA-N

Chemical Structure

2D Structure

CAS: 2088852-47-3

CID: 90279868

Formula: C26H26F3N5O3

MW: 513.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	513.5
XLogP3	1.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	4
Exact Mass	513.19877419
Monoisotopic Mass	513.19877419
Topological Polar Surface Area	125 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	803
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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C13679-5mg	Uzansertib (INCB053914)
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BUP09043-01	Uzansertib phosphate
M23938-01	INCB053914 phosphate
HY-101870B-01	Uzansertib (phosphate)
A21444-50	INCB053914 phosphate 50mg
A21444-10	INCB053914 phosphate 10mg
A21444-100	INCB053914 phosphate 100mg
A21444-25	INCB053914 phosphate 25mg

Uzansertib (INCB053914)

Chemical Information

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