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AZ32

CAT: 0957-S8729-10mM/1mLSize: 10 mM/1mLDry Ice: NoHazardous: No
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CAT#:0957-S8729-10mM/1mLSize:10 mM/1mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2288709-96-4
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Smiles
CNC (=O) C1=CC=C (C=C1) C2=CN=C3C=NC (=C[N]23) C4=CC=CC=C4
Molecular Formula
C20H16N4O
Additionnal Information
AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.
Storage Conditions
3 years -20°C powder

Chemical Information

N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
CAS Number2288709-96-4
PubChem CID134814488
IUPAC NameN-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
Molecular FormulaC20H16N4O
Molecular Weight328.4
XLogP3.3
Topological Polar Surface Area59.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity457
SMILES
CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=CC=C4
InChI
InChI=1S/C20H16N4O/c1-21-20(25)16-9-7-15(8-10-16)18-11-23-19-12-22-17(13-24(18)19)14-5-3-2-4-6-14/h2-13H,1H3,(H,21,25)
InChIKey
LCRTUEXVVKVKBD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
CAS: 2288709-96-4
CID: 134814488
Formula: C20H16N4O
MW: 328.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight328.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass328.13241115
Monoisotopic Mass328.13241115
Topological Polar Surface Area59.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity457
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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