Products for Research Use Only
RegisterLogin

Fisogatinib (BLU-554)

CAT: 0957-S8503-5mgSize: 5 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0957-S8503-5mgSize:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1707289-21-1
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=CC (=C (C (=C1Cl) C2=CC3=CN=C (N=C3C=C2) NC4COCCC4NC (=O) C=C) Cl) OC
Molecular Formula
C24H24Cl2N4O4
Additionnal Information
Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.
Storage Conditions
2 years -80 in solvent

Chemical Information

Fisogatinib

Fisogatinib is under investigation in clinical trial NCT04194801 (A Phase Ib/ii Study of Fisogatinib(blu-554) in Subjects With Hepatocellular Carcinoma).

CAS Number1707289-21-1
PubChem CID91885617
IUPAC NameN-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide
Molecular FormulaC24H24Cl2N4O4
Molecular Weight503.4
XLogP4.7
Topological Polar Surface Area94.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity688
SMILES
COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC
InChI
InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1
InChIKey
MGZKYOAQVGSSGC-DLBZAZTESA-N
Chemical Structure
2D Structure
2D structure of Fisogatinib
CAS: 1707289-21-1
CID: 91885617
Formula: C24H24Cl2N4O4
MW: 503.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight503.4
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass502.1174606
Monoisotopic Mass502.1174606
Topological Polar Surface Area94.6 Ų
Heavy Atom Count34
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
E1952-1gBLU-222
E1176-5mgBLU-945
E1952-5mgBLU-222
E1176-10mM/1mLBLU-945
E1176-25mgBLU-945
E1952-01BLU-222
E1952-100mgBLU-222
E1176-100mgBLU-945
E1952-25mgBLU-222
E1176-01BLU-945

Alternative Products

CatalogName
C13455-01Fisogatinib (BLU-554)
B8391-100BLU-554
BB160379-01BLU 554
527807Fisogatinib
A20354-5Fisogatinib 5mg
HY-100492RFisogatinib (Standard)
A20354-10Fisogatinib 10mg
A20354-500Fisogatinib 500mg
A20354-100Fisogatinib 100mg

Popular Products