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L-2-Hydroxyglutaric acid disodium

CAT: 0957-S1325-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S1325-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
63512-50-5
Synonyms
(S) -2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG
Target
Histone Demethylase
Applications
Epigenetics
Smiles
[Na+].[Na+].OC (CCC ([O-]) =O) C ([O-]) =O
Molecular Formula
C5H6Na2O5
Additionnal Information
L-2-Hydroxyglutaric acid disodium ((S) -2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.
Storage Conditions
3 years -20°C powder

Chemical Information

Sodium (S)-2-hydroxypentanedioate

L-alpha-hydroxyglutaric acid disodium salt is an organic molecular entity. It has a role as an animal metabolite.

CAS Number63512-50-5
PubChem CID56845267
IUPAC Namedisodium;(2S)-2-hydroxypentanedioate
Molecular FormulaC5H6Na2O5
Molecular Weight192.08
Topological Polar Surface Area100
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count12
Formal Charge0
Complexity130
SMILES
C(CC(=O)[O-])[C@@H](C(=O)[O-])O.[Na+].[Na+]
InChI
InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
InChIKey
DZHFTEDSQFPDPP-QTNFYWBSSA-L
Chemical Structure
2D Structure
2D structure of Sodium (S)-2-hydroxypentanedioate
CAS: 63512-50-5
CID: 56845267
Formula: C5H6Na2O5
MW: 192.08
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight192.08
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass192.00106185
Monoisotopic Mass192.00106185
Topological Polar Surface Area100 Ų
Heavy Atom Count12
Formal Charge0
Complexity130
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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Alternative Products

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A22281-100L-2-Hydroxyglutaric acid disodium 100mg
A22281-50L-2-Hydroxyglutaric acid disodium 50mg
A22281-25L-2-Hydroxyglutaric acid disodium 25mg
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