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Genistein-d4

CAT: 0804-HY-14596SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14596SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis[1][2].
CAS Number
187960-08-3
Product Name Alternative
NPI 031L-d4
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; EGFR; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
98.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C2=C(C([2H])=C(C([2H])=C2[2H])O)[2H])=COC3=CC(O)=CC(O)=C31
Molecular Formula
C15H6D4O5
Molecular Weight
274.26
Precautions
H302
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Peterson G, et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7 (10) :1345-51.|[3]Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11 (5) :e0155352.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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