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RMC5127

CAT: 0957-E6403-1mgSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-E6403-1mgSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ras
Applications
Apoptosis
Additionnal Information
RMC5127 is a first-in-class, orally bioavailable mutant-selective tri-complex inhibitor of the GTP-bound (ON) form of RASG12V. It non-covalently binds to cyclophilin A (CypA), forming a binary complex that engages RASG12V (ON) to form a high-affinity tri-complex, sterically inhibiting RAS binding. It inhibits the RAS pathway in KRASG12V-mutant cancer cells, reducing proliferation, inducing apoptosis, and showing strong potential for use in RASG12V-mutated cancer research.

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CatalogName
T204085-01RMC5127

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