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Hydroxychloroquine

CAT: 0957-E4824-1gSize: 1 gDry Ice: NoHazardous: No
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CAT#:0957-E4824-1gSize:1 g
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CAS Number
118-42-3
Synonyms
HCQ
Target
Autophagy
Applications
Autophagy
Molecular Formula
C18H26ClN3O
Additionnal Information
Hydroxychloroquine (HCQ) is an antimalarial drug that inhibits autophagy and is used to treat systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) . It exhibits immunomodulatory, antithrombotic, and antiplatelet properties. It inhibits the release endothelin-1, a potent vasoconstrictor, and restores impaired angiogenesis in TNF-α-treated endothelial cells in vitro. It also reduces the production of inflammatory cytokines such as TNF-α, IFN-γ, and IL-6 from peripheral blood mononuclear cells, upregulates IL-10 and decreases platelet aggregation.

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