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Afatinib free base

CAT: 0957-E4819-1gSize: 1 gDry Ice: NoHazardous: No
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CAT#:0957-E4819-1gSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
439081-18-2
Synonyms
Gilotrif, BIBW2992, Boehringer Ingelheim
Target
EGFR
Applications
Protein Tyrosine Kinase
Molecular Formula
C24H25ClFN5O3
Additionnal Information
Afatinib free base (Gilotrif, BIBW2992, Boehringer Ingelheim) is a second-generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 14 nM and 1 nM for wild-type EGFR, EGFR-L858R, HER2, ErbB4, respectively.

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