Products for Research Use Only
RegisterLogin

SRX3177

CAT: 0957-E4702-1gSize: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0957-E4702-1gSize:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2241237-51-2
Target
CDK
Applications
Cell Cycle
Molecular Formula
C31H32N6O4S
Additionnal Information
SRX3177 is a potent triple inhibitor targeting CDK4/6, PI3K, and BRD4, with IC50 values of 33 nM for BRD4 BD1, 89 nM for BRD4 BD2, 79 nM for PI3Kα, 83 nM for PI3Kδ, 3.18 μM for PI3Kγ, <2.5 nM for CDK4, and 3.3 nM for CDK6. By simultaneously inhibiting these key pathways, SRX3177 disrupts cancer cell signalling and exhibits significant cytotoxic effects in tumors.

Chemical Information

7-cyclopentyl-N,N-dimethyl-2-((4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS Number2241237-51-2
PubChem CID153289441
IUPAC Name7-cyclopentyl-N,N-dimethyl-2-[4-(5-morpholin-4-yl-7-oxothieno[3,2-b]pyran-3-yl)anilino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
Molecular FormulaC31H32N6O4S
Molecular Weight584.7
XLogP4.7
Topological Polar Surface Area130
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count42
Formal Charge0
Complexity1020
SMILES
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7
InChI
InChI=1S/C31H32N6O4S/c1-35(2)30(39)24-15-20-17-32-31(34-29(20)37(24)22-5-3-4-6-22)33-21-9-7-19(8-10-21)23-18-42-28-25(38)16-26(41-27(23)28)36-11-13-40-14-12-36/h7-10,15-18,22H,3-6,11-14H2,1-2H3,(H,32,33,34)
InChIKey
XJKTXWSMMWPNTP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-cyclopentyl-N,N-dimethyl-2-((4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS: 2241237-51-2
CID: 153289441
Formula: C31H32N6O4S
MW: 584.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight584.7
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass584.22057470
Monoisotopic Mass584.22057470
Topological Polar Surface Area130 Ų
Heavy Atom Count42
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
S8948-25mgSRX3207
S8948-01SRX3207
S8948-5mgSRX3207

Alternative Products

CatalogName
C03292-01SRX3177
A24272-100SRX3177 100mg
A24272-50SRX3177 50mg
A24272-5SRX3177 5mg
A24272-10SRX3177 10mg

Popular Products