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NX-1607

CAT: 0957-E1957-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1957-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2573775-59-2
Synonyms
Cbl-b-IN-3
Target
E3 Ligase
Applications
Ubiquitin
Molecular Formula
C30H34F3N5O
Additionnal Information
NX-1607 (Cbl-b-IN-3) is an oral inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), which is an E3 ubiquitin ligase and a key regulator of T, NK, and dendritic cell activation and suppresses their anti-tumor functions. NX-1607 enhances antigen recall, reduces T cell exhaustion, and increases cytokine production in response to T cell receptor stimulation, thereby counteracting suppressive signals from the tumor microenvironment.

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