UNC5293

CAT: 0957-E1744-5mgSize: 5 mgDry Ice: NoHazardous: No

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CAT#:0957-E1744-5mgSize:5 mg

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CAS Number

2226789-82-6

Target

Mertk

Applications

Protein Tyrosine Kinase

Molecular Formula

C30H42N6O2

Additionnal Information

UNC5293 is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 of 0.9 nM and Ki 0.19 nM.

Chemical Information

(2,6-dimethyl-4-pyridinyl)-[4-[7-(4-hydroxycyclohexyl)-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-5-yl]piperidin-1-yl]methanone

CAS Number	2226789-82-6
PubChem CID	146403042
IUPAC Name	(2,6-dimethyl-4-pyridinyl)-[4-[7-(4-hydroxycyclohexyl)-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-5-yl]piperidin-1-yl]methanone
Molecular Formula	C30H42N6O2
Molecular Weight	518.7
XLogP	4.6
Topological Polar Surface Area	96.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Heavy Atom Count	38
Formal Charge	0
Complexity	758

SMILES

CCC[C@H](C)NC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4CCN(CC4)C(=O)C5=CC(=NC(=C5)C)C

InChI

InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19,22,24-25,37H,5-14H2,1-4H3,(H,31,33,34)/t19-,24?,25?/m0/s1

InChIKey

MSWOWUREQODTRO-CCYWVKEMSA-N

Chemical Structure

2D Structure

CAS: 2226789-82-6

CID: 146403042

Formula: C30H42N6O2

MW: 518.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	518.7
XLogP3	4.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	518.33692460
Monoisotopic Mass	518.33692460
Topological Polar Surface Area	96.2 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	758
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS5825295	UNC5293

UNC5293

Chemical Information

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