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EN450

CAT: 0957-E1575-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1575-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
793719-01-4
Target
NF-κB
Applications
NF-κB
Molecular Formula
C11H13ClN2O3S
Additionnal Information
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. It interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D that induces the ternary complex formation between UBE2D and NFKB1. It exhibits anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.

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