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UNC6934

CAT: 0957-E1059-25mgSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1059-25mgSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2561494-77-5
Target
NSD
Applications
Epigenetics
Smiles
O=C1COC2=C (N1) C=CC (=C2) C (=O) N (CC3=CC=C (C=C3) C (=O) NC4=CC=NC=N4) C5CC5
Molecular Formula
C24H21N5O4
Additionnal Information
UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.
Storage Conditions
3 years -20°C powder

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