C-KIT Mutation Detection Kit

CAT: 1219-3B1342Size: 48 ReactionsDry Ice: NoHazardous: No
CAT#:1219-3B1342Size:48 Reactions
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Description
• CE-IVD • TRUPCR® C-KIT mutation detection Kit allows sensitive and specific detection of most common D816V in single run. • The kit offers sensitivity to detect up to 1% mutant allele in background of 99% wild type alleles. • It is compatible with various Real Time PCR instruments • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.
Applications Notes
The TRUPCR® C-KIT Mutation Detection is a PCR-based in vitro diagnostic test designed to detect D816V in the C-KIT gene in genomic DNA extracted from peripheral blood of patients diagnosed with acute myelogenous leukemia (AML) or other malignancy. KIT is a receptor tyrosine kinase involved in proliferation, differentiation, and survival. KIT mutations affect predominantly exons 8 or 17, lead to a gain of function, and occur in 2%–14% of all cases of AML. The incidence of KIT mutations is higher in core-binding factor leukemia, being found in about 7%–46% of cases. The presence of KIT mutations in core binding factor leukemia is generally accepted to be associated with a worse prognosis. The D816V mutation results in an amino acid substitution at position 816 in KIT, from an aspartic acid (D) to a valine (V) . This mutation is associated with intermediate prognosis in AML in patients with t (8;21), inv (16), or t (16;16) karyotype. In patients without KIT mutations, t (8;21), inv (16), and t (16;16) are associated with favorable prognosis.

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