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CKS-17

CAT: 1601-CCP1155-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1601-CCP1155-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Peptide to CKS-17
CAS Number
99273-04-8
Structure Composition
H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu-OH
Applications
LQNRRGLDLLFLKEGGL corresponds to a highly conserved region of the immunosuppressive retroviral envelope protein p15E. CKS-17 has been shown to inhibit lymphocyte proliferation, B cell activation, natural killer cell cytotoxicity, and monocyte-mediated tumor cytotoxicity. S.Haraguchi et al. demonstrated that CKS-17 induces rises in intracellular cAMP levels that may affect several physiological cellular functions.
Purity
> 95%
Form
Lyophilized powder
Molecular Formula
C87H148N26O24
Molecular Weight
1942.31
Storage Conditions
Shipped at 4°C. Store at -20°C for one year.
Light Source
Synthetic

Chemical Information

Cks 17

16-amino acid protein; has been synthesized; homologous to the first 16 amino acids of the P15E region of HTLV I & II & HIV

CAS Number99273-04-8
PubChem CID16130962
IUPAC Name(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-5-amino-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]acetyl]amino]-4-methylpentanoic acid
Molecular FormulaC87H148N26O24
Molecular Weight1942.3
XLogP-7
Topological Polar Surface Area840
Hydrogen Bond Donor Count29
Hydrogen Bond Acceptor Count28
Rotatable Bond Count71
Heavy Atom Count137
Formal Charge0
Complexity4050
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O)N
InChI
InChI=1S/C87H148N26O24/c1-44(2)32-51(89)72(123)103-56(25-27-65(90)114)77(128)112-62(39-66(91)115)83(134)106-54(24-19-31-97-87(94)95)76(127)104-52(23-18-30-96-86(92)93)73(124)100-43-69(118)101-57(33-45(3)4)78(129)113-63(40-71(121)122)84(135)110-59(35-47(7)8)80(131)108-60(36-48(9)10)81(132)111-61(38-50-20-14-13-15-21-50)82(133)109-58(34-46(5)6)79(130)105-53(22-16-17-29-88)75(126)107-55(26-28-70(119)120)74(125)99-41-67(116)98-42-68(117)102-64(85(136)137)37-49(11)12/h13-15,20-21,44-49,51-64H,16-19,22-43,88-89H2,1-12H3,(H2,90,114)(H2,91,115)(H,98,116)(H,99,125)(H,100,124)(H,101,118)(H,102,117)(H,103,123)(H,104,127)(H,105,130)(H,106,134)(H,107,126)(H,108,131)(H,109,133)(H,110,135)(H,111,132)(H,112,128)(H,113,129)(H,119,120)(H,121,122)(H,136,137)(H4,92,93,96)(H4,94,95,97)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
InChIKey
RESSROXEVCGJLA-DFNTYYFDSA-N
Chemical Structure
2D Structure
2D structure of Cks 17
CAS: 99273-04-8
CID: 16130962
Formula: C87H148N26O24
MW: 1942.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1942.3
XLogP3-7
Hydrogen Bond Donor Count29
Hydrogen Bond Acceptor Count28
Rotatable Bond Count71
Exact Mass1941.1159797
Monoisotopic Mass1941.1159797
Topological Polar Surface Area840 Ų
Heavy Atom Count137
Formal Charge0
Complexity4050
Isotope Atom Count0
Defined Atom Stereocenter Count14
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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412992Cks 17
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