RANKL (soluble) (human), (recombinant)

CAT: 1106-ALX-522-012-C010Size: 10 µgDry Ice: NoHazardous: No

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CAT#:1106-ALX-522-012-C010Size:10 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Product Name Alternative

TRANCE, OPGL, ODF, TNFSF 11, CD254

Certification

RUO

UniProt

O14788

Source

Produced in HEK 293 cells. The extracellular domain of human RANKL (aa 152-317) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG ® -tag.

Stability

Stable for at least 6 months after receipt when stored at -20°C.

Concentration

0.1 mg/mL after reconstitution.

Endotoxin

<0.1EU/μg purified protein (LAL test; Associates of Cape Cod) .

Purity

≥90% (SDS-PAGE)

Reconstitution

Reconstitute with 100μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

Solubility

Soluble in water.

Molecular Weight

~18kDa (non-glycosylated), ~28kDa (glycosylated) (SDS-PAGE) .

Shipping Conditions

Blue Ice

Storage Conditions

-20°C

Notes

FLAG is a registered trademark of Sigma-Aldrich Co.

Specificity

Binds to human and mouse RANK.

Formulation

Lyophilized. Contains PBS.

Applications Notes

ELISA: binds to RANK receptor.

UniProtKB · O14788

Tumor necrosis factor ligand superfamily member 11

TNF11_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O14788
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TNFSF11
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: TNFSF11
EC number: —
Processing: —
Secondary accessions: O14723, Q96Q17, Q9P2Q3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembraneSecreted

Molecular function

CytokineDevelopmental proteinReceptor

Biological process

Differentiation

Disease

Disease variantOsteopetrosis

PTM

Glycoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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