IL-12, Mouse (HEK293, Fc)

IL-12, Mouse (HEK293, Fc)

• UNSPSC Description: Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine[1][2]. IL-12 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of IL-12A (M1-A215) and IL-12B (M1-S335).
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/il-12-protein-mouse-hek293-fc.html
• Molecular Weight: Approximately 55&75 kDa
• References & Citations: [1]Ivy M Dambuza, et al. IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease. Nat Commun. 2017 Sep 28;8(1):719.|[2]Jin Kyeong Choi, et al. IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis. Front Immunol. 2017 Oct 5;8:1258.
• Shipping Conditions: Room temperature