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TPMPA (hydrate)

CAT: 0607-C8598-10Size: 10 mgDry Ice: NoHazardous: No
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Description
TPMPA is a selective competitive antagonist for GABAA-ρ (also known as GABAC) receptors, particularly showing selectivity for the ρ1 subtype over ρ2.
CAS Number
182485-36-5
Product Name Alternative
(R) -methyl (1,2,3,6-tetrahydropyridin-4-yl) phosphinic acid
Purity
0.98
Solubility
Soluble in DMSO
Smiles
O[P@@] (C1=CCNCC1) (C) =O
Molecular Formula
C6H12NO2P.XH2O
Molecular Weight
161.1
Storage Conditions
-20°C, stored under nitrogen, protect from light

Chemical Information

Tpmpa

TPMPA ((1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid) is a selective antagonist of GABAC receptors (also known as GABA-ρ or GABAA-ρ receptors). GABAC receptors are found primarily in the retina, although they may be present in other tissues, including the hippocampus, spinal cord, superior colliculus, pituitary and the gut. TPMPA is used as a pharmacological probe for the investigation of GABAC receptor function.

CAS Number182485-36-5
PubChem CID5521
IUPAC Namemethyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid
Molecular FormulaC6H12NO2P
Molecular Weight161.14
XLogP-3.5
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count10
Formal Charge0
Complexity200
SMILES
CP(=O)(C1=CCNCC1)O
InChI
InChI=1S/C6H12NO2P/c1-10(8,9)6-2-4-7-5-3-6/h2,7H,3-5H2,1H3,(H,8,9)
InChIKey
MFUKVPOVVKKLRQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tpmpa
CAS: 182485-36-5
CID: 5521
Formula: C6H12NO2P
MW: 161.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight161.14
XLogP3-3.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass161.06056562
Monoisotopic Mass161.06056562
Topological Polar Surface Area49.3 Ų
Heavy Atom Count10
Formal Charge0
Complexity200
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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