Olmutinib (BI 1482694)

CAT: 1568-C18152Size: 100 mgDry Ice: YesHazardous: No

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CAT#:1568-C18152Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1353550-13-6

Synonyms

HM61713

SKU

C18152-100mg

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CN1CCN (CC1) C2=CC=C (C=C2) NC3=NC4=C (C (=N3) OC5=CC=CC (=C5) NC (=O) C=C) SC=C4

Molecular Formula

C26H26N6O2S

Additionnal Information

Olmutinib (BI 1482694) is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI) . Also a potent inhibitor of Bruton's tyrosine kinase.

Storage Conditions

2 years -80 in solvent

Chemical Information

Olmutinib

Olmutinib is an orally active epidermal growth factor receptor inhibitor used in the treatment of T790M mutation positive non-small cell lung cancer. It is available under the brand name Olita made by Hanmi Pharmaceuticals. Olmutinib was developed by Hanmi Pharmaceuticals and Boehringer Ingelheim. Olmutinib recieved breakthrough therapy designation in the United States in December 2015 and was approved for use in Korea in May 2016.

CAS Number	1353550-13-6
PubChem CID	54758501
IUPAC Name	N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Molecular Formula	C26H26N6O2S
Molecular Weight	486.6
XLogP	4.7
Topological Polar Surface Area	111
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Heavy Atom Count	35
Formal Charge	0
Complexity	712

SMILES

CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4

InChI

InChI=1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

InChIKey

FDMQDKQUTRLUBU-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1353550-13-6

CID: 54758501

Formula: C26H26N6O2S

MW: 486.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	486.6
XLogP3	4.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	486.18379527
Monoisotopic Mass	486.18379527
Topological Polar Surface Area	111 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	712
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
S8294-25mg	Olmutinib (BI 1482694)
B7813-5.1	Olmutinib (HM61713, BI 1482694)
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GTR19163767-01	Olmutinib (b)
MBS5812670	Olmutinib hydrochloride
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HY-19730A	Olmutinib (hydrochloride)

Olmutinib (BI 1482694)

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